Regrapex-R®
Resveratrol, Curcumin, Boswellia and Green tea catechins were reviewed as natural immunomodulators with an excellent safety profile and a promising potential for treating inflammations, such as IBD (inflammatory bowel disease).
The New York Times (June 4, 2008), by Nicholas Wade
New Hints Seen That Red Wine May Slow Aging
Scientists from the University of Wisconsin conducted a study comparing mice fed resveratrol with mice on a caloric-restricted diet and mice on a normal diet. In the resveratrol fed mice, the same effects on gene expression, associated with heart, brain and skeletal muscle aging, were found as in the caloric-restricted mice. The researchers concluded that resveratrol can mimic many of the effects of a caloric-restricted diet at doses that can readily be achieved in humans and suggested that dietary consumption of relatively low doses of resveratrol partially mimics caloric restriction and inhibits some aspects of the aging process.
Barger JL, Kayo T, Vann JM, Arias EB, Wang J, et al. (2008)
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.
http://www.ncbi.nlm.nih.gov/Abstract
Clarke JO, Mullin GE.
A review of complementary and alternative approaches to immunomodulation.
http://www.ncbi.nlm.nih.gov/Abstract
Auger C, Teissedre PL, Gerain P, Lequeux N, Bornet A, Serisier S, Besancon P, Caporiccio B, Cristol JP, Rouanet JM.
Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation.
http://www.ncbi.nlm.nih.gov/Abstract
Busquets S, Ametller E, Fuster G, Olivan M, Raab V, Argiles JM, Lopez-Soriano FJ.
Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model.
http://www.ncbi.nlm.nih.gov/Abstract
Corder R, Douthwaite JA, Lees DM, Khan NQ, Viseu Dos Santos AC, Wood EG, Carrier MJ.
Endothelin-1 synthesis reduced by red wine.
http://www.ncbi.nlm.nih.gov/Abstract
Das DK, Maulik N.
Resveratrol in cardioprotection: a therapeutic promise of alternative medicine.
http://www.ncbi.nlm.nih.gov/Abstract
Delmas D, Jannin B, Latruffe N.
Resveratrol: preventing properties against vascular alterations and ageing.
http://www.ncbi.nlm.nih.gov/Abstract
Folts JD.
Potential health benefits from the flavonoids in grape products on vascular disease.
http://www.ncbi.nlm.nih.gov/uids=12083471&dopt=Abstract
Garvin S, Ollinger K, Dabrosin C.
Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo.
http://www.ncbi.nlm.nih.gov/Abstract
Harper CE, Patel BB, Wang J, Arabshahi A, Eltoum IA, Lamartiniere CA.
Resveratrol suppresses prostate cancer progression in transgenic mice.
http://www.ncbi.nlm.nih.gov/Abstract
Kampa M, Hatzoglou A, Notas G, Damianaki A, Bakogeorgou E, Gemetzi C, Kouroumalis E, Martin PM, Castanas E.
Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines.
http://www.ncbi.nlm.nih.gov/Abstract
Marambaud P, Zhao H, Davies P.
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.
http://www.ncbi.nlm.nih.gov/Abstract
Martin AR, Villegas I, Sanchez-Hidalgo M, de la Lastra CA.
The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model.
http://www.ncbi.nlm.nih.gov/Abstract
Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM.
The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease.
http://www.ncbi.nlm.nih.gov/uids=7554275dopt=Abstract
Shanmuganayagam D, Beahm MR, Osman HE, Krueger CG, Reed JD, Folts JD.
Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans.
http://www.ncbi.nlm.nih.gov/uids=12468593&dopt=Abstract
Soleas GJ, Diamandis EP, Goldberg DM.
Wine as a biological fluid: history, production, and role in disease prevention.
http://www.ncbi.nlm.nih.gov/Abstract
Sovak M.
Grape Extract, Resveratrol, and Its Analogs: A Review.
http://www.ncbi.nlm.nih.gov/Abstract
Vigna GB, Costantini F, Aldini G, Carini M, Catapano A, Schena F, Tangerini A, Zanca R, Bombardelli E, Morazzoni P, Mezzetti A, Fellin R, Maffei Facino R.
Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers.
http://www.ncbi.nlm.nih.gov/uids=14564675&dopt=Abstract
Vinson JA, Proch J, Bose P.
MegaNatural((R)) Gold Grapeseed Extract: In Vitro Antioxidant and In Vivo Human Supplementation Studies.
http://www.ncbi.nlm.nih.gov/uids=12639284&dopt=Abstract
Zern TL, West KL, Fernandez ML.
Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs.
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