GMP Nutraceuticals
X-Ray Contrast MediaBioswellix
Boswellia serrata, the Indian Olibanum tree, has been widely used in Ayurvedic and other traditional Asian medicines. Its extract was reported to have anti-inflammatory activity and is being used in a variety of conditions such as asthma, various skin diseases, arthritis, as well as gastrointestinal afflictions such as ulcerative colitis, Crohn´s disease and chronic liver inflammation.
The active substances of Boswellia serrata were shown to be the triterpenes, contained in the plant resin. Among these triterpenes, the boswellic acids proved to be effective anti-inflammatory and immuno-modulating agents by selectively inhibiting the inflammatory enzymes 5-lipooxygenase and leukocyte elastase. Boswellic acids were also shown to inhibit endothelin-1, one of the many allergy factors, without side effects. Boswellic acids act synergistically with other phytochemicals that have been shown to have activity against a variety of chronic inflammatory conditions and immunological disturbances and have been used for the regulation of cellular growth.
As it often happens with natural products, the most biologically effective substances are only minor components of the plant extract. Thus, consumption of many grams would be necessary to induce a substantial pharmacological effect. The currently commercially available extracts of Boswellia serrata contain only low amounts of boswellic acids, approximately 25 % by weight or less.
Most producers specify the potency of Boswellia serrata extracts by the “total organic acids content,” inferring that this reflects the content of the boswellic acids. This is misleading because, besides boswellic acids, there are many other acidic components within the extract, many of which have no reported biological value. In contrast, the quality of Bioswellix is specified by the content of the biologically active components, determined by a precise chromatographic analysis.
Boswellia
serrata
Common names:
Olibanum, Frankincense, Salai Gugal (Guggul)
Family: Burseraceae
Origin: India
Bioswellix contains minimally 50 % (by weight) triterpenes consisting of the significant boswellic acids and up to 20 % of other active triterpenes, predominantly 3-oxo-tirucallic acid (3-OTA). Up to 80 % of the boswellic acid group consists of the most pharmacologically active components, -acetyl-β -boswellic acid (ABA) and 3-acetyl-11-keto-β-boswellic acid (AKBA). In most commercial preparations, the composite content of the AKBA and ABA rarely exceeds 15%. The enhanced content of these important substances in Bioswellix is achieved by a proprietary extraction and enrichment technology.
Thus compared to the standard commercial products, Bioswellix reduces the quantity of extract needed to be consumed in order to achieve a meaningful dose. Hepacept® is synergistic herbal extract composition which contains Bioswellix and was developed by Interpharma Praha in collaboration with Biophysica, Inc. of San Diego, California.