diindolylmethane (DIM)

Diindolylmethane (DIM) is an important nutritional phytochemical. Its unstable precursor, indole-3-carbinol (I-3C), is converted into DIM during mastication of cruciferous vegetables. Both substances have previously been shown to prevent cancer in animals and it has become generally accepted that, like many other nutraceuticals, DIM has a role to play in the prevention of cancer by regulating cellular growth.

Unlike the inherently unstable I-3C, DIM provides for a predictable response. A recent study has shown that uterine cervical dysplasia, a known precancerous condition, responds well to the orally administered indoles.

Current and more extensive studies of women with cervical dysplasia, and also of children with papillomatosis of larynx (http://www.rrpwebsite.org), are being conducted with DIM rather than I-3C to achieve predictable pharmacokinetics.

Phytochemicals, such as DIM, and other components derived from cruciferous vegetables demonstrated antitumorigenic activity and their use as nutraceuticals has been increasing. Interpharma produces crystalline DIM of high quality under good manufacturing practice. BioResponse, a Colorado, USA company, markets a proprietary formulation of an orally resorbable DIM (http://www.bioresponse.com).

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