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Resveratrol, Curcumin, Boswellia and Green tea catechins were reviewed as natural immunomodulators with an excellent safety profile and a promising potential for treating inflammations, such as IBD (inflammatory bowel disease).

Clarke JO, Mullin GE.
A review of complementary and alternative approaches to immunomodulation.

http://www.ncbi.nlm.nih.gov/Abstract

Sarkar FH, Li Y.
Indole-3-carbinol and prostate cancer. J Nutr. 2004 Dec;134(12 Suppl):3493S-3498S.

http://www.ncbi.nlm.nih.gov/Abstract

Garikapaty VP, Ashok BT, Tadi K, Mittelman A, Tiwari RK.
Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer. Prostate. 2006 Apr 1;66(5):453-62.

http://www.ncbi.nlm.nih.gov/Abstract

Sasieni P.
Chemoprevention of cervical cancer. Best Pract Res Clin Obstet Gynaecol. 2006 Apr;20(2):295-305. Epub 2006 Jan 4.

http://www.ncbi.nlm.nih.gov/Abstract

Winking M, Sarikaya S, Rahmanian A, Jodicke A, Boker DK.
Boswellic acids inhibit glioma growth: a new treatment option?

http://www.ncbi.nlm.nih.gov/uids=10894362

Dong H, Lu FE, Gao ZQ, Xu LJ, Wang KF, Zou X.
Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw.

http://www.ncbi.nlm.nih.gov/Abstract

Zhang XP, Li ZF, Liu XG, Wu YT, Wang JX, Wang KM, Zhou YF.
Effects of emodin and baicalein on rats with severe acute pancreatitis.

http://www.ncbi.nlm.nih.gov/Abstract

Shoskes DA, Zeitlin SI, Shahed A, Rajfer J.
Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology. 1999 Dec;54(6):960-3.

http://www.ncbi.nlm.nih.gov/Abstract

Knowles LM, Zigrossi DA, Tauber RA, Hightower C, Milner JA
Flavonoids suppress androgen-independent human prostate tumor proliferation. Nutr Cancer. 2000;38(1):116-22

http://www.ncbi.nlm.nih.gov/Abstract

van Loon IM.
The golden root: Clinical applications of Scutellaria baicalensis Georgi. Flavonoids as modulators of the inflammatory response

http://www.thorne.com

Miocinovic R, McCabe NP, Keck RW, Jankun J, Hampton JA, Selman SH.
In vivo and in vitro effect of baicalein on human prostate cancer cells. Int J Oncol. 2005 Jan;26(1):241-6.

http://www.ncbi.nlm.nih.gov/Abstract

Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A.
Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res. 2006 Jan 15;66(2):1234-40.

http://www.ncbi.nlm.nih.gov/Abstract

Busquets S, Ametller E, Fuster G, Olivan M, Raab V, Argiles JM, Lopez-Soriano FJ.
Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model.

http://www.ncbi.nlm.nih.gov/Abstract

Garvin S, Ollinger K, Dabrosin C.
Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo.

http://www.ncbi.nlm.nih.gov/Abstract

Harper CE, Patel BB, Wang J, Arabshahi A, Eltoum IA, Lamartiniere CA.
Resveratrol suppresses prostate cancer progression in transgenic mice.

http://www.ncbi.nlm.nih.gov/Abstract

Soleas GJ, Grass L, Josephy PD, Goldberg DM, Diamandis EP.
A comparison of the anticarcinogenic properties of four red wine polyphenols.

http://www.ncbi.nlm.nih.gov/uids=11983346&dopt=Abstract

Kampa M, Hatzoglou A, Notas G, Damianaki A, Bakogeorgou E, Gemetzi C, Kouroumalis E, Martin PM, Castanas E.
Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines.

http://www.ncbi.nlm.nih.gov/uids=11142097&dopt=Abstract

Sovak M.
Grape Extract, Resveratrol, and Its Analogs: A Review.

http://www.ncbi.nlm.nih.gov/uids=12639418&dopt=Abstract

Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM.
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.

http://www.ncbi.nlm.nih.gov/uids=8985016&dopt=Abstract

Fremont L.
Biological effects of resveratrol.

http://www.ncbi.nlm.nih.gov/uids=10680575&dopt=Abstract

Igura K, Ohta T, Kuroda Y, Kaji K.
Resveratrol and quercetin inhibit angiogenesis in vitro.

http://www.ncbi.nlm.nih.gov/uids=11485823&dopt=Abstract

De Santi C, Pietrabissa A, Spisni R, Mosca F, Pacifici GM.
Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum.

http://www.ncbi.nlm.nih.gov/uids=10923862&dopt=Abstract

Paul B, Masih I, Deopujari J, Charpentier C.
Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India.

http://www.ncbi.nlm.nih.gov/uids=10624864&dopt=Abstract

Sovak M, Hajduch M, Masner O, Endlicherova P, Prokop J. UCSD Dept of Radiology and Biophysics, La Jolla, CA; Lab of Exp Medicine, Palacky Univ Med School, Olomouc, Czech Republic; Interpharma Praha, Prague, Czech Republic.
PSA rising syndrome: Resorption, synergism and potential utility of t-resveratrol, its glycon piceid and curcumin.

http://aacr03.agora.com/planner/displayabstract.asp?presentationid=6849

Gao X, Xu YX, Janakiraman N, Chapman RA, Gautam SC.
Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production.

http://www.ncbi.nlm.nih.gov/uids=11705464&dopt=Abstract

Duvoix A, Blasius R, Delhalle S, Schnekenburger M, Morceau F, Henry E, Dicato M, Diederich M.
Chemopreventive and therapeutic effects of curcumin.

http://www.ncbi.nlm.nih.gov/uids=15896452&dopt=Abstract

Garcea G, Berry DP, Jones DJ, Singh R, Dennison AR, Farmer PB, Sharma RA, Steward WP, Gescher AJ.
Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.

http://www.ncbi.nlm.nih.gov/uids=15668484&dopt=Abstract

Leclercq IA , Farrell GC, Sempoux C, dela Pena A, Horsmans Y.
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice.

http://www.ncbi.nlm.nih.gov/uids=15582125&dopt=Abstract

Jones DJ, Lamb JH, Verschoyle RD, Howells LM, Butterworth M, Lim CK, Ferry D, Farmer PB, Gescher AJ.
Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity.

http://www.ncbi.nlm.nih.gov/uids=15292928&dopt=Abstract

Olas B, Wachowicz B, Majsterek I, Blasiak J.
Resveratrol may reduce oxidative stress induced by platinum compounds in human plasma, blood platelets and lymphocytes.

http://www.ncbi.nlm.nih.gov/uids=15930895&dopt=Abstract

Azmi AS, Bhat SH, Hadi SM.
Resveratrol-Cu(II) induced DNA breakage in human peripheral lymphocytes: Implications for anticancer properties.

http://www.ncbi.nlm.nih.gov/uids=15919081&dopt=Abstract

Miatello R, Vazquez M, Renna N, Cruzado M, Zumino AP, Risler N.
Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats.

http://www.ncbi.nlm.nih.gov/uids=15925749&dopt=Abstract

Elmali N, Esenkaya I, Harma A, Ertem K, Turkoz Y, Mizrak B.
Effect of resveratrol in experimental osteoarthritis in rabbits.

http://www.ncbi.nlm.nih.gov/uids=15883738&dopt=Abstract

Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E.
Inhibition of influenza a virus replication by resveratrol.

http://www.ncbi.nlm.nih.gov/uids=15838800&dopt=Abstract

Auger C, Teissedre PL, Gerain P, Lequeux N, Bornet A, Serisier S, Besancon P, Caporiccio B, Cristol JP, Rouanet JM.
Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation.

http://www.ncbi.nlm.nih.gov/uids=15769129&dopt=Abstract

Zhou HB, Chen JJ, Wang WX, Cai JT, Du Q.
Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice.

http://www.ncbi.nlm.nih.gov/uids=15633232&dopt=Abstract

Miura D, Miura Y, Yagasaki K.
Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats.

http://www.ncbi.nlm.nih.gov/uids=12850500&dopt=Abstract

Zern TL, West KL, Fernandez ML.
Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs.

http://www.ncbi.nlm.nih.gov/uids=12840191&dopt=Abstract

Jing XB, Ueki N, Cheng JD, Imanishi H, Hada T
Induction of apoptosis in hepatocellular carcinoma cell lines by emodin

http://www.ncbi.nlm.nih.gov/uids=12716464&dopt=Abstract

Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, Rao CV, Reddy BS.
Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.

http://www.ncbi.nlm.nih.gov/uids=9973206&dopt=Abstract

Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, Pirmohamed M, Marnett LJ, Gescher AJ, Steward WP.
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.

http://www.ncbi.nlm.nih.gov/uids=11448902&dopt=Abstract

Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE.
Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo.

http://www.ncbi.nlm.nih.gov/uids=11398177&dopt=Abstract

Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM.
Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile.

http://www.ncbi.nlm.nih.gov/uids=10729246&dopt=Abstract

Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S.
Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity.

http://www.ncbi.nlm.nih.gov/uids=12710595&dopt=Abstract

Aggarwal BB, Kumar A, Bharti AC.
Anticancer potential of curcumin: preclinical and clinical studies.

http://www.ncbi.nlm.nih.gov/uids=12680238&dopt=Abstract

Chainani-Wu N.
Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).

http://www.ncbi.nlm.nih.gov/uids=12676044&dopt=Abstract

Greenwald P, Milner JA, Anderson DE, McDonald SS.
Micronutrients in cancer chemoprevention.

http://www.ncbi.nlm.nih.govAbstract

Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY.
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

http://www.ncbi.nlm.nih.gov/uids=11712783

Prucksunand C, Indrasukhsri B, Leethochawalit M, Hungspreugs K.
Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer.

http://www.ncbi.nlm.nih.gov/uids=11485087&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Satoskar RR, Shah SJ, Shenoy SG.
Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation.

http://www.ncbi.nlm.nih.gov/uids=3546166&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Chauhan DP.
Chemotherapeutic potential of curcumin for colorectal cancer.

http://www.ncbi.nlm.nih.gov/uids=12171541&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Reddy BS, Rao CV.
Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors.

http://www.ncbi.nlm.nih.gov/uids=12171541&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

http://www.ncbi.nlm.nih.gov/uids=11398177&dopt=Abstract http://www.ncbi.nlm.nih.govuids=12549762&dopt=Abstract

Li JK, Lin-Shia SY.
Mechanisms of cancer chemoprevention by curcumin.

http://www.ncbi.nlm.nih.gov/uids=11370761&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Ramsewak RS, DeWitt DL, Nair MG.
Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa.

http://www.ncbi.nlm.nih.gov/uids=10969724&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/uids=12549762&dopt=Abstract

Rao CV, Rivenson A, Simi B, Reddy BS.
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

http://www.ncbi.nlm.nih.gov/uids=7812955&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Araujo CC, Leon LL.
Biological activities of Curcuma longa L.

http://www.ncbi.nlm.nih.gov/uids=11500779&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Ammon HP, Wahl MA.
Pharmacology of Curcuma longa.

http://www.ncbi.nlm.nih.gov/uids=2062949&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Cha TL, Qiu L, Chen CT, Wen Y, Hung MC.
Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.

http://www.ncbi.nlm.nih.gov/uids=15781642dopt=Abstract

Jing XB, Ueki N, Cheng JD, Imanishi H, Hada T
Induction of apoptosis in hepatocellular carcinoma cell lines by emodin

http://www.ncbi.nlm.nih.gov/uids=12716464&dopt=Abstract

http://www.ncbi.nlm.nih.gov/uids=9973206&dopt=Abstract

http://www.ncbi.nlm.nih.gov/uids=11448902&dopt=Abstract

http://www.ncbi.nlm.nih.gov/uids=11398177&dopt=Abstract

Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM.
Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile.

http://www.ncbi.nlm.nih.gov/uids=10729246&dopt=Abstract

http://www.ncbi.nlm.nih.gov/uids=12710595&dopt=Abstract

Aggarwal BB, Kumar A, Bharti AC.
Anticancer potential of curcumin: preclinical and clinical studies.

http://www.ncbi.nlm.nih.gov/uids=12680238&dopt=Abstract

Chainani-Wu N.
Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).

http://www.ncbi.nlm.nih.gov/uids=12676044&dopt=Abstract

Greenwald P, Milner JA, Anderson DE, McDonald SS.
Micronutrients in cancer chemoprevention.

http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

http://www.ncbi.nlm.nih.gov/uids=11712783

Prucksunand C, Indrasukhsri B, Leethochawalit M, Hungspreugs K.
Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer.

http://www.ncbi.nlm.nih.gov/uids=11485087&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Satoskar RR, Shah SJ, Shenoy SG.
Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation.

http://www.ncbi.nlm.nih.gov/uids=3546166&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Chauhan DP.
Chemotherapeutic potential of curcumin for colorectal cancer.

http://www.ncbi.nlm.nih.gov/uids=12171541&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Reddy BS, Rao CV.
Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors.

http://www.ncbi.nlm.nih.gov/uids=12171541&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

http://www.ncbi.nlm.nih.gov/uids=11398177&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Li JK, Lin-Shia SY.
Mechanisms of cancer chemoprevention by curcumin.

http://www.ncbi.nlm.nih.gov/uids=11370761&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Ramsewak RS, DeWitt DL, Nair MG.
Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa.

http://www.ncbi.nlm.nih.gov/uids=10969724&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Rao CV, Rivenson A, Simi B, Reddy BS.
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

http://www.ncbi.nlm.nih.gov/uids=7812955&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Araujo CC, Leon LL.
Biological activities of Curcuma longa L.

http://www.ncbi.nlm.nih.gov/uids=11500779&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Ammon HP, Wahl MA.
Pharmacology of Curcuma longa.

http://www.ncbi.nlm.nih.gov/uids=2062949&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Cha TL, Qiu L, Chen CT, Wen Y, Hung MC.
Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.

http://www.ncbi.nlm.nih.gov/uids=15781642dopt=Abstract

Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS.
Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

http://www.ncbi.nlm.nih.gov/uids=9619120&dopt=Abstract

Khajuria A, Zutshi U, Bedi KL.
Permeability characteristics of piperine on oral absorption - an active alkaloid from peppers and a bioavailability enhancer.

http://www.ncbi.nlm.nih.gov/uids=9536651&dopt=Abstract

Badmaev V V, Majeed M, Prakash L.
Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation.

http://www.ncbi.nlm.nih.gov/uids=10715596&dopt=Abstract

Johri RK, Zutshi U.
An Ayurvedic formulation 'Trikatu' and its constituents.

http://www.ncbi.nlm.nih.gov/uids=1434692&dopt=Abstract

Atal CK, Zutshi U, Rao PG.
Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.

http://www.ncbi.nlm.nih.gov/uids=7311598&dopt=Abstract

Atal CK, Dubey RK, Singh J.
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.

http://www.ncbi.nlm.nih.gov/uids=3917507&dopt=Abstract

Knekt P, Kumpulainen J, Jarvinen R, Rissanen H, Heliovaara M, Reunanen A, Hakulinen T, Aromaa A.
Flavonoid intake and risk of chronic diseases.

http://www.ncbi.nlm.nih.gov/uids=12198000&dopt=Abstract

Ferrandina G, Almadori G, Maggiano N, Lanza P, Ferlini C, Cattani P, Piantelli M, Scambia G, Ranelletti FO.
Growth-inhibitory effect of tamoxifen and quercetin and presence of type II estrogen binding sites in human laryngeal cancer cell lines and primary laryngeal tumors.

http://www.ncbi.nlm.nih.gov/uids=9688309&dopt=Abstract

Xing N, Chen Y, Mitchell SH, Young CY.
Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells.

http://www.ncbi.nlm.nih.gov/uids=11238180&dopt=Abstract

Shoskes DA, Zeitlin SI, Shahed A, Rajfer J.
Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial.

http://www.ncbi.nlm.nih.gov/uids=10604689&dopt=Abstract

Corder R, Douthwaite JA, Lees DM, Khan NQ, Viseu Dos Santos AC, Wood EG, Carrier MJ.
Endothelin-1 synthesis reduced by red wine.

http://www.ncbi.nlm.nih.gov/uids=11780050&dopt=Abstract http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

Vijayakumar RS, Surya D, Nalini N.
Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress.

http://www.ncbi.nlm.nih.gov/uids=15231065&dopt=Abstract
http://www.ncbi.nlm.nih.gov/uids=12549762&dopt=Abstract

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