GMP Nutraceuticals
Regrapex-R®
whole grape extract enriched with resveratrol
Our extract maintains the natural balance of all biologically active components (polyphenolic acids, flavanols, flavonoids, anthocyanins and OPC´s - oligomeric proanthocyanidins) of red grapes, grown in Southern France and produced under the European Community rules for environmentally controlled agriculture. Such balanced whole grape extract has been shown in the scientific literature to be superior to a manipulated product in reducing blood cholesterol.
It is known that the polyphenols contained in red wine are responsible for the s.c. “French paradox,” i.e. why did the French in the South who used to consume a lot of red wine regularly have lower frequency of cardiovascular diseases compared to the other populations? Red wine polyphenols and particularly resveratrol and its analogs are powerful antioxidants and free-radical scavengers which were shown to have salutary cardiovascular effects. Resveratrol was shown to lower the blood fats and cholesterol levels, as well as the intrinsic hypertensive agent endothelin-1. Also, resveratrol was found to be a natural regulator of cellular growth, suggesting cancer preventative value.
Resveratrol is not an indispensable component of red grapes or wine. It is synthesized by Vitis vinifera, as needed, as a defense against parasites. Once abundant (up to 8 - 20 mg per liter) in red wine, it is now almost absent due to the use of pesticides. Our Regrapex-R® is enriched with this important compound, which is extracted from other plants, and standardized to a minimum of 100 mg trans-resveratrol per 1gram.
This product is prepared, analyzed and certified under Good Manufacturing Practice rules in a plant inspected by the National Regulatory Authorities.
This product was developed by Interpharma Praha in collaboration with Biophysica, Inc. of San Diego, California.
Resveratrol HP and Resveratrol-Glycon HP
(High Purity products)
trans-Resveratrol is a natural plant antibiotic produced by grape vines, Vitis vinifera, as a response to combat molds. As a result of pesticide use, there are presently only traces of resveratrol in red wine. trans-Resveratrol and its natural analogs are found in a number of plants, but it is most conveniently extracted from Polygonum cuspidatum, a plant widely used in traditional Asian herbal medicine.
Recently, the New York Times (Jun. 4, 2008) commented on an article published in Public Library of Science (for abstract, see “references”). In summary, scientists from the University of Wisconsin reported a study comparing mice fed resveratrol with mice on a caloric-restricted diet and control mice on a normal diet. In the resveratrol fed mice, the same effects on gene expression, associated with heart, brain and skeletal muscle aging, were found as in the caloric-restricted mice. The researchers concluded that resveratrol can mimic many of the effects of a caloric-restricted diet and suggested that dietary consumption of resveratrol mimics caloric restriction and inhibit certain aspects of the aging process.
This new data further supports the results of a 2006 study published in the journal Nature (for abstract, see “references”) where mice were fed a high calorie fatty diet with one group also receiving a daily supplement of 22.4 mg/kg resveratrol. New York Times author Nicholas Wade wrote:
As there is not more than 1-3 mg t-resveratrol per liter of red wine, the daily dose used in mice for this experiment roughly corresponds to 1.7 g in man or the equivalent to consuming hundreds of liters of red wine. Most of the commercially available extracts contain only a small fraction of resveratrol or the resveratrol glycon, the remainder consisting of unidentified and/or undeclared impurities of unknown biological properties. A natural food supplement with such important properties and anti-aging effects should have a precisely defined composition. This is why a pharmaceutial grade, high purity resveratrol is needed.
Resveratrol is one of nature’s most potent free radical scavengers and antioxidants. Its antihyperlipidemic and antihypertensive effects, cholesterol lowering capabilities, salutary effects on cellular growth regulation and immune responses have been widely published in the scientific literature. The anti-aging properties of resveratrol may well be connected to the above, although specific mechanisms have been hypothesized (see “references”).
Resveratrol in its natural form is predominantly found coupled to a sugar (i.e., "glycon"), which makes the poorly soluble parent compound, trans-resveratrol, more water soluble. Also, the glycon is highly orally bioavailable and its stability is much greater compared to resveratrol without the sugar moiety (see reference Prokop et al.). Most commercial extracts are usually of low purity and contain many unidentified impurities including emodin, which in doses as low as 10 mg/day can produce diarrhea.
We are aware that the customers are increasingly concerned about the quality and safety of imported products. Our food supplements are rigorously handled under GMP (Good Manufacturing Practice) rules of the European Union and FDA. Both our HP products are certified to meet the analytical standards, for more details please see the specifications.
specification (High Purity Resveratrol)
specification (High Purity Resveratrol glycon)
Our research and development facilities discovered a new technology for manufacturing high purity, pharmaceutical grade trans-resveratrol and resveratrol-glycon. Resveratrol HP and Resveratrol-Glycon HP are prepared, analyzed and certified under Good Manufacturing Practice guidelines in a plant inspected by National Regulatory Authorities. The products were approved as nutritional supplements in the Czech Republic.
Resveratrol HP and Resveratrol-Glycon HP were developed by Biophysica Research of San Diego, California and are manufactured by Interpharma Praha
Hepacept®
synergistic composition of plant extracts
The herbs contained in Hepacept® are traditionally known for their anti-inflammatory properties and are utilized as preventative agents as well as nutritional supplements for the medical treatment of chronic inflammation of various organs such as the liver, urinary bladder, intestines and the joints.
The composition of Hepacept® is based on synergies of its active principles discovered in our laboratories. Developed by Biophysica, Inc. of La Jolla, California, and Interpharma Praha, Hepacept® contains the following concentrated, purified and analytically standardized herbal extracts (in mg per 1 g of the composition):
Extract from the resin of Olibanum tree (165 mg) Boswellia serrata
- contains 60 - 70 % by weight boswellic acids and other active triterpenes
more info about the product: “Bioswellix”
Resveratrol extract (200 mg)
- contains min. 50 % by weight trans-resveratrol
Extract of the root of Baical skullcap (165 mg) Scutellaria baicalensis
- contains min. 80 % by weight baicalin monohydrate
Extract of the root of turmeric (334 mg) Curcuma longa
- contains min. 90 % by weight curcuminoids
Extract of the fruit
of Milk thistle (133 mg) Silybum
marianum
- contains min. 60 % silymarin (UV), min. 30% by weight silybinin (HPLC)
Extract from dried
fruits of black pepper (3 mg) Piper
nigrum
- contains min. 90 % by weight piperine
These individual herbs are used in traditional Ayurvedic and Asian folk medicines. Baical skullcap, for example, is part of the traditional Japanese treatment for chronic inflammation, including that of the liver and its sequel, liver cirrhosis. Boswellia resin is used in India for allergic and other conditions suggesting its immuno-modulating properties.
Resveratrol is also used for a variety of inflammatory and neoplastic diseases in traditional chinese medicine.
Silymarin, derived from Milk thistle, is a well-known and widely used herbal substance listed in several Pharmacopoeias as an adjuvant treatment for chronic liver inflammation. Studies in animals and human subjects have shown Silymarin to assist the body, especially the liver, in providing protection against toxic substances, such as the side effects of chemotherapeutics, and in working synergistically with the drugs to enhance therapeutic effects. For example, Silymarin have been found to reduce toxic effects of cisplatin upon the kidneys in animals without compromising the drug's anti-tumor activity. Similar tests involving adriamycin have found similar results. For the corresponding scientific referrences, please click here:
A small amount of piperine, extracted from black pepper, has been added as it was shown to increase oral absorption.
Hepacept® components are effective antioxidants and free-radical scavengers. They have also been reported to be inhibitors of unregulated cell growth, which occurs under conditions such as inflammation and neoplastic afflictions. Curcumin, derived from Turmeric, is one of the most extensively studied.
This product is prepared, analyzed and certified under Good Manufacturing Practice rules in a plant inspected by the National Regulatory Authorities.
This product was developed by Interpharma Praha in collaboration with Biophysica, Inc. of San Diego, California.
Bioswellix
Boswellia serrata, the Indian Olibanum tree, has been widely used in Ayurvedic and other traditional Asian medicines. Its extract was reported to have anti-inflammatory activity and is being used in a variety of conditions such as asthma, various skin diseases, arthritis, as well as gastrointestinal afflictions such as ulcerative colitis, Crohn´s disease and chronic liver inflammation.
The active substances of Boswellia serrata were shown to be the triterpenes, contained in the plant resin. Among these triterpenes, the boswellic acids proved to be effective anti-inflammatory and immuno-modulating agents by selectively inhibiting the inflammatory enzymes 5-lipooxygenase and leukocyte elastase. Boswellic acids were also shown to inhibit endothelin-1, one of the many allergy factors, without side effects. Boswellic acids act synergistically with other phytochemicals that have been shown to have activity against a variety of chronic inflammatory conditions and immunological disturbances and have been used for the regulation of cellular growth.
As it often happens with natural products, the most biologically effective substances are only minor components of the plant extract. Thus, consumption of many grams would be necessary to induce a substantial pharmacological effect. The currently commercially available extracts of Boswellia serrata contain only low amounts of boswellic acids, approximately 25 % by weight or less.
Most producers specify the potency of Boswellia serrata extracts by the “total organic acids content,” inferring that this reflects the content of the boswellic acids. This is misleading because, besides boswellic acids, there are many other acidic components within the extract, many of which have no reported biological value. In contrast, the quality of Bioswellix is specified by the content of the biologically active components, determined by a precise chromatographic analysis.
Boswellia
serrata
Common names:
Olibanum, Frankincense, Salai Gugal (Guggul)
Family: Burseraceae
Origin: India
Bioswellix contains minimally 50 % (by weight) triterpenes consisting of the significant boswellic acids and up to 20 % of other active triterpenes, predominantly 3-oxo-tirucallic acid (3-OTA). Up to 80 % of the boswellic acid group consists of the most pharmacologically active components, -acetyl-β -boswellic acid (ABA) and 3-acetyl-11-keto-β-boswellic acid (AKBA). In most commercial preparations, the composite content of the AKBA and ABA rarely exceeds 15%. The enhanced content of these important substances in Bioswellix is achieved by a proprietary extraction and enrichment technology.
Thus compared to the standard commercial products, Bioswellix reduces the quantity of extract needed to be consumed in order to achieve a meaningful dose. Hepacept® and Resquerin® are synergistic herbal extract compositions which contain Bioswellix and were developed by Interpharma Praha in collaboration with Biophysica, Inc. of San Diego, California.
Bio-Quercetin
Quercetin, a substance marketed as a food supplement, is present in many plants, but for practical purposes it is derived from rutin (quercetin-3-O-rhamnoglucoside), which is treated with acid to obtain quercetin. Rutin is isolated from the seed pods of the Brazilian shrub “fava d´anta” (Dimorphandra mollis). There is significant evidence in the literature concerning anti-proliferative and cell growth regulating properties of quercetin.
Most of these studies were carried out in vitro (cell culture). Quercetin in vivo, however, is poorly resorbed from the gastrointestinal tract. Fortunately, another form of quercetin, isoquercitrin (quercetin-3-O-glucoside), is much better resorbed due to the carbohydrate portion of the molecule. Its increased resorption, compared to quercetin and rutin, has been amply documented in the literature.
Interpharma Praha has developed a proprietary procedure for conversion of the inactive precursors in Dimorphandra mollis to the biologically resorbable and therefore active isoquercitrin. This product is a concentrated and purified herbal extract which is analytically standardized to contain min. 50% (w/w) isoquercitrin.
This product is prepared, analyzed and certified under Good Manufacturing Practice rules in a plant inspected by the National Regulatory Authorities.
diindolylmethane
A dietary indole of proven modifying activity of estrogens and the papilloma virus. Clinical studies suggest usefulness in precancerosis of the cervix of uterus and papillomatosis of the larynx. Recently proposed as a prostate cancer preventative.
Interpharma developed a unique synthesis of pure GMP crystalline DIM (diindolylmethane) and has filed DMF. DIM is especially formulated by a proprietary technology and marketed as a nutraceutical and food supplement by Bioresponse of Colorado, USA. www.bioresponse.com.
C.A.S. No.: [1968-05-4]
3,3' -Bis(Indolyl)methane
